
This study is conducted to evaluate the seroprevalence of HBV, HCV, HIV and syphilis among blood donors in a tertiary care hospital of piparia, waghodia a five and half year experience. Total 10386 blood donors came to Dhiraj general hospital to donate blood during Jan2006-Aug2011were selected for the study. Seroprevalence of HBV, HCV and HIV was studied by ELISA in voluntary and replacement blood donors. RPR was done for screening of syphilis. The seroprevalence of HIV, HBV, HCV and syphilis is found to be 0.25%, 1.35%, 0.16% and 0.9% respectively. Infections are slightly more common among replacement donors compared to voluntary donors. There is a gradual decrease of TTIs in blood donors over the years due to following of stringent blood donor selection criteria.