Evaluation of platelet indices and platelet counts and their significance in pre-eclampsia and eclampsia

Authors:Vamseedhar Annam, Srinivasa Kenchaiah, Santosh K Yatnatti, Suresh DR
Int J Biol Med Res. 2011; 2(1): 425 – 428  |  PDF File

Abstract

Background: Although it is generally accepted that the hemoglobin concentration decreases and white cell count increases during normal pregnancy, there is less accord regarding changes in platelet indices. The aim of this study is to find out the relationship between platelet indices and platelet counts with pre-eclampsia and eclampsia. Material and Methods: 82 cases of preeclampsia and 63 cases of eclampsia diagnosed between the years September 2007 and December 2009 were evaluated prospectively. One hundred healthy pregnant women with similar demographic features and gestational age and without the diagnosis of preeclampsia, gestational or chronic hypertension and proteinuria were included in the study as the control group. Blood samples were analyzed by automated hematology analyzer. The platelet count, mean platelet volume, platelet distribution width and platelet large cell ratio were compared. Results: The platelet counts were lower while the mean platelet volume, platelet distribution width and platelet large cell ratio were increased in pre-eclampsia and eclampsia as compared to control group. Conclusion: We found a relationship between platelet indices and severity of pre-eclampsia. The estimation of platelet indices can be considered as an early, simple and rapid procedure in the assessment of severity of pre-eclampsia.