Evaluation of biochemical parameters evincing atherogenic potency in type 2 diabetic retinopathy
Authors:Int J Biol Med Res. 2011; 2(2): 539 – 542
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Title - Evaluation of Biochemical parameters evincing atherogenic potency in Type 2 Diabetic Retinopathy.
Objectives- Poor glycemic control leads to hypomagnesemia, uncontrolled hyperglycemia associated with high incidence of micro vascular complications such as retinopathy, nephropathy and cardiovascular problems in type 2 Diabetes mellitus. The chief aim of the study is to obtain possible biochemical indices level in all the groups.
Materials and methods- The current study was under taken in total 90 subjects divided in to three groups, includes thirty control (Group-1), thirty diabetics with out complications of retinopathy (Group-2) and thirty diabetics with retinopathy (Group-3). Fasting Blood sugar level, fructosamine, magnesium, microalbuminuria, cholesterol, triglycerides, LDL-cholesterol and HDL-cholesterol were analyzed in all the groups.
Results-Decreased serum magnesium observed in Group-3 compared to Group-1 was a significant observation and also significant correlation present between fructosamine, magnesium and microalbuminuria level. Our study results also indicate that the diabetic retinopathy patients have hypercholesterolemia, hypertriglyceridemia, elevated LDL-cholesterol lipoprotein fraction and significantly decreased HDL-cholesterol lipoprotein fraction which are responsible for micro vascular changes.
Conclusion- Hypomagnesemia, hyperglycemia, increased fructosamine and increased lipid profile with decreased HDL-cholesterol level indicates the probability and possibility of atherogenicity.