Antioxidants status in haemodialysis patients

Abstract

People with advanced chronic renal failure (CRF) who have progressed to end stage renal disease (ESRD) usually require dialysis. The aim of treatment by dialysis is to replace all the lost functions of the natural kidneys, as far as possible using artificial means. The process of separating solutes using semi permeable membrane in vitro and termed the word Dialysis. It is more efficient in terms of rapidly removing wastes. The patients blood is pumped through an artificial kidney machine. Importantly, major antioxidant trials have observed a neutral effect of vitamin E, a lipid-soluble reactive species scavenger, on cardiovascular outcomes. In a biologic system, free radical attack takes place in the presence of an unbalanced ratio between free radicals and antioxidants. OS is likely to be involved in the development of complications due to hemodialysis. Though there is evidence for production of oxygen free radicals during hemodialysis, reports on net oxidative imbalance due to a single dialysis session are conflicting. Vitamin E, being associated with lipoproteins, is not cleared during dialysis. So, a decrease in the level is mostly because of consumption in its attempt to reduce the effect of oxygen free radicals generated during hemodialysis.