study of correlation between oxidative stress parameters and severity of pre-eclampsia

Abstract

ABSTRACT: Back ground: Preeclampsia is characterized by hypertension and proteinuria. Hypertensive disorders are the most common medical complications of pregnancy. In preeclampsia, oxidative stress is exaggerated. This was undertaken to correlate oxidative stress parameters and severity of preeclampsia. Methods: Twenty five (25) subjects were randomly selected who are attending hospital. Blood samples collected analysed for total antioxidant capacity (TAC) and Malondialdehyde(MDA) and correlated with Diastolic Blood Pressure(DBP), Proteinuria Uric acid and other parameters. Results: Subjects with proteinuria show significant increase in TAC values. There is a positive correlation between DBP and proteinuria. Uric acid and TAC were significantly correlating with DBP. Conclusion: Oxidative parameters like TAC were strongly co-relating with DBP, proteinuria and uric acid levels which indicates severityty of Pre-eclampsia.