Study of serum uric acid and c - reactive protein levels in patients with chronic renal disease

Authors:Pravin N. BAravkar, Jayashree S. BAvikar, Shilpa B. Asegaonkar, Suhas S. Bavikar, Jayashree S. Bardapurkar,Anand P. Thorat
Int J Biol Med Res. 2013; 4(1): 2758-2761  |  PDF File

Abstract

Background: Chronic kidney disease (CKD) is a worldwide health problem rising at alarming rate. Patients with CKD are at high risk for cardiovascular disease (CVD) and are more likely to die of CVD than to develop end-stage renal failure. Either inflammation or hyperuricemia has been related with increased cardiovascular risk and mortality. A hypothetical relationship between serum uric acid levels and CRP has been tested recently in chronic renal disease patients. Aims: Present study was planned to evaluate the serum C-reactive protein and uric acid levels and correlate them with Glomerular filtration rate (GFR) in patients of chronic kidney disease. Methods: 45 cases of diagnosed CKD on conservative treatment or dialysis were selected. They were categorized into stage 4 and 5 depending on GFR. Serum C- reactive protein and uric acid levels were estimated in them. Results: In our study group serum CRP and uric acid levels were raised significantly in all patients. Also it is found that the increase in serum uric acid level from mean7.7 mg/dL in stage 4 CKD to mean 8.5 mg/dL in stage 5 CKD is statistically significant (p < 0.01). Mean CRP in studied patients was found to be elevated (mean 7.7+/-1.8 mg/L). Serum CRP value was found to be elevated in 80 % of patients in stage 4 and in 88 % of patients of stage 5 CKD. Furthermore increase in mean serum CRP from mean 7.1 mg/L in stage 4 CKD to mean 8.2 mg/L in stage 5 CKD is also statistically significant (p < 0.05) Conclusion: CRP estimation in CKD is helpful in predicting an increased risk of cardiovascular death. Either inflammation or hyperuricemia has been related with increased cardiovascular risk and mortality.