The circulating markers of inflammation and insulin sensitivity in southern indian adult subjects: associations with age, gender and different degree of body mass index

Authors:Desigamani Kanniyappan *, Rita Mary Aruna
Int J Biol Med Res. 2013; 4(1): 2807-2812  |  PDF File

Abstract

Abstract:Important biochemical markers for the low-grade inflammation that characterize the earliest events in the pathogenesis of atherosclerosis are CRP and cytokine IL-6. This study aims to evaluate, in healthy Southern Indian adult subjects aged 20–59 years, the association of CRP, IL-6with their age, gender, different degree of body mass and insulin sensitivity.Methods: There were 490 subjects (228 males and 262females) aged 20–59 yrs. All had detailed clinical examination, anthropometry (BMI, WC and WHR) and assessment of fasting Blood glucose, serum levels of CRP, IL-6 and insulin and Insulin resistance by HOMA-IR. Associations with accepted determinants were explored by regression analyses. Results and conclusion: Increase levels of inflammation and insulin resistance were observed in the overweight and obese males of 40 - 59 age group of the south Indian adults. Thus it can be concluded that an increase level of inflammation and insulin resistance were observed in the overweight and obese males of 40 - 59 age group of the south Indian adults as compared to other group that are studied