A study of carotid intima medial thickness among diabetic and non diabetic patients and its association with the vascular complications – a comparative study.

Authors:ArunKumar.R , Lokesh.S
Int J Biol Med Res. 2013; 4(2): 3078- 3083  |  PDF File

Abstract

ABSTRACT Introduction: the incidence and prevalence of diabetes mellitus is on a rise as a result of changing environmental and social factors, increased risk of metabolic syndrome and increased longevity. Survival of the diabetic patients has increased due to the advent of newer and effective drugs for managing diabetes mellitus. Diabetic patients are often seen suffering from micro and macro vascular complication which has become a major factor increasing mortality and morbidity. There is a need to have a sensitive and cost effective investigation which is capable of identifying the vascular complications at a much earlier stage. Carotid Intima Medial thickness is one such accessible structure which can be studied to risk stratify the patient with diabetes mellitus and an early effective therapy can be introduced to prevent further progression of the vascular insult. Material and methods: study was carried out by the Department of General Medicine, Sri LakshmiNarayana Institute of Medical Sciences, Puducherry. Patients attending medicine OPD were divided in to Diabetic group and Non Diabetic group after considering exclusion criteria. Both the groups were subjected to relevant biochemical and radiological investigations. Results were analysed with appropriate statistical methods. Results: hypertension was the common comorbid illness found in diabetic group. Diabetic group had significantly higher SBP, DBP, HbA1C, TC, TG, LDL-C and low HDL-C. The CIMT and the vascular complications was significantly higher in diabetic group. Conclusion: CIMT was positively associated with greater overall risk of vascular events in diabetic group .Vascular events of all forms were significantly seen in those patients with increased CIMT. Hence the detection of abnormal CIMT predicts the risk of vascular complications in diabetic patients.