Comparison of drotaverine and valethamate bromide in first stage of labor

Authors:Jayashree S, Virupaksha Ajjammanavar, Sujatha M.S
Int J Biol Med Res. 2013; 4(2): 3215- 3218  |  PDF File

Abstract

AIM: To compare the efficacy and side effects of drotaverine and valethamate bromide in first stage of labor. METHOD: This study is a randomized prospective study done in JSS Hospital, Mysore, consisting of 200 pregnant women, 100 of whom were given drotaverine and 100, valethamate bromide when they entered active phase of labor, i.e., when cervix was 3-4 cm dilated and uterine contractions were effective. Drotaverine 40 mg was given IM 2nd hourly to a maximum of 3 doses and valethamate bromide was given half hourly to a maximum of 3 doses. RESULTS: The rate of cervical dilatation was more in the drotaverine group (3.31 cm/hr in primigravida and 3.71 cm/hr in multigravida) compared to valethamate group (2.58 cm/hr in primigravida and 2.61 cm/hr in multigravida). More number of women (72.9% of primigravida and 78.8% of multigravida) delivered within 2 hours in the drotaverine group compared to valethamate group. The difference was statistically significant. 72.9% of primigravida and 78.8% of multigravida required only 1 injection of drotaverine while 98.1% of primigraviadas and 100% of multigravidas required 3 injections of epidosin. No significant maternal or fetal side effects were noted with both the drugs. CONCLUSION: Drotaverine is more effective than valethamate bromide in reducing the duration of active phase of labour. No major maternal or fetal side effects were noted in this study.