Evaluation of biochemical and bone density parameters in premenopausal and postmenopausal women

Authors:Muni Radha Jada, Balananda Perugu, Suneetha, Suneetha Chalasani, Parvathi G
Int J Biol Med Res. 2013; 4(3): 3441-3443  |  PDF File

Abstract

Osteoporosis is a bone disease of low bone mass and bone tissue deterioration resulting in an increased risk of fracture. The objective of this study was to analyse biochemical and bone density measurements on the dual energy X-Ray absorptiometry (DEXA) instrument among postmenopausal women in comparison to premenopausal women. A cross-sectional prospective study was carried including 20 premenopausal women of 25-40 years age and 20 postmenopausal women of 40-70 years age. Biochemical markers and bone density measures at the regions of lumbar spine (L1-L4), neck of the femur and forearm were assessed among all subjects. An unpaired student t-test was used to test differences between groups. The significance level was set at a statistical value, p<0.05. Serum phosphorus and alkaline phosphatase levels were low in l postmenopausal women in comparison to premenopausal group. There were significant differences between groups in bone mineral content, bone mineral density, T-score and Z-score measures. Among all the three regions studied for bone density, lumbar spine was found to be at increased risk. The present study results suggest that postmenopausal women are at increased risk for osteoporosis. We recommend that postmenopausal women should be screened for osteoporotic fracture risk which might be an important strategy in the management of postmenopausal osteoporotic risk.