Antiulcer activity of polycarpaea corymbosa (l.) lam. whole plant extracts (caryophyllaceae

Authors:Balamurugan K, Sakthidevi G, Mohan V.R.
Int J Biol Med Res. 2013; 4(3): 3379-3382  |  PDF File

Abstract

The objective of this study was to investigate the antiulcer activity of whole plant of Polycarpaea corymbosa in rats. Antiulcer effects of the ethanol extracts at 250 and 500 mg/Kg were evaluated in rats using ethanol induced and indomethacin induced ulcer models. Phytochemical analysis was carried out using standard procedure. Results showed that the ethanol extract exhibited significant and dose dependent antiulcer activity in the models used. Percentage ulcer inhibitions of extract at 500 mg/Kg for ethanol and indomethacin induced ulcer were 67.27% and 62.72% respectively. Ulcer protection in the model used by the extract is dose dependent and the ulcer inhibitory effects of the extract are comparable to omeperazole. Therefore, a result of the present study suggests that the ethanol extract of Polycarpaea corymbosa possesses antiulcer activity