Highlights of p53 mutation and itís role in cervical cancer metastasis

Authors:Gracy.G, Sadhna.K, Jacqueline.J,Deepika.K
Int J Biol Med Res. 2014; 5(1): 3772-3779  |  PDF File

Abstract

Cervical cancer, is a disease that has the potential to be prevented, and is still the second most common cancer that becomes progressively worse in women worldwide. Human papillomavirus is the single most important disease causing agent in cervical cancer. HPV contributes to abnormal progression of cells through the action of two viral oncoproteins E6 and E7, which interfere with critical cell cycle pathways, p53, and retinoblastoma. The p53 gene like the Rbgene, is a tumor suppressor gene, i.e., its activity stops the formation of tumors. However, mutations in p53 are found in most tumor types, and so leads to the complex network of molecular events leading to tumor formation. Primary HPV positive anogenital cancers normally develop without somatic mutation within the p53 gene. In this study, however, we have identified p53 point mutations in metastases arising from HPV positive cervical carcinomas. The association of p53 mutation with metastases may explain the poor prognosis reported for HPV negative primary cancers, many of which already contain mutant p53. A high proportion of p53 mutations detected in both primary and metastatic cancers are GC-->TA transversions, strongly suggesting a role for external carcinogens in the development of these cancers. The present article discusses about the mutation in p53, which can cause metastases in primary cervical cancer.