Correlation between antimicrobial consumption and changes in susceptibility patterns of enterobacteriacae over three years in a tertiary care hospital

Authors: VL Chaudhari , SS Gunjal , MC Mehta
Int J Biol Med Res. 2014; 5(1): 3810-3816  |  PDF File

Abstract

Aims: To evaluate the antibacterial resistance pattern in the three financial years, to determine annual consumption of antibacterial agents, and to find out the trend of antibacterial resistance pattern with respect to annual consumption of antibacterial agents Methods: The present study is an observational, longitudinal, descriptive type of drug utilization studyover the three financial years conducted in a tertiary care hospital in Central India.Antimicrobial resistance pattern and the annual consumption of the antimicrobial agents is obtained from the hospital data & compared by appropriate analytic methodusing Graph Pad Prism version 5.01 and EpiInfo version 3.5 software. Results: Total 52,344 biological samples tested for culture positivity, out of which only 10,542 (20%) were showed growth of bacteria. Out of these 10,542 samples 69.3% were from the Enterobacteriacae family. The annual consumption of Aminopenicillin and Fluoroquinolone was high as compared to other antimicrobial agents. When the resistance pattern and annual consumption were compared with each other, positive trend was found in Aminopenicillin, Gentamicin and Cefotaxime group with statistical significance of p<0.5. Conclusion: The observations of present study can help to improve the rational use of ABAs in indoor patients and also to curtail the economic burden of our tertiary care hospital. Hence, we expect that such type of studies should be done in every hospital to provide a base for formulating the local antibacterial guideline.