Present status of antihypertensive drugs associated with other cardiovascular diseases in bangladesh

Authors:Md. Sheam Biswas , Md. Reyad-ul-ferdous, *, Fariha Tasnim , Nahida Akhter , Md. Naimul Islam , Mohsina Mukti
Int J Biol Med Res. 2014; 5(3): 4239-4245  |  PDF File

Abstract

Aims: To correlate treatment management of anti-hypertension and cardiovascular diseases. Methods: In this studied a cross sectional observational was done on 200 patients among them 152 were male and 48 were female to find out the commonly used drugs for the treatment of hypertension and to determine the impact of different other risk factors on hypertension and associated cardiac diseases. Results: In this study a number of generics were found that included Beta blockers Metoprolol (16%), Carvedilol (14%), Atenolol (6%); Calcium channel blocker Amlodipine (17%); Diuretics Furosemide + Spironolactone (16%); Angiotensin receptor blockers Losartan (8%); ACE inhibitors Ramipril (14%), Captopril (9%). An important observation is that Beta blockers are mostly used as antihypertensive. The prospect of Beta blocker is due to its compelling indication in post MI patients. Different other generics were also found that were used for the management of other cardiac problems. Among them antiplatelet agents like Aspirin + Clopidogrel (33%), Aspirin (6%) were predominant for the prevention of further heart attack, stroke and peripheral vascular disease. Lipid lowering agent like Atorvastatin (24%) was also found in a significant percentage. Other drugs were Vasodilator like Glyceryl trinitrate (23%), Cardiac glycocides like Digoxin (4%), Anti-ischemic like Trimetazidine HCl (7%) and Anticoagulants like Warfarin (3%). During the study other factors like sex, occupation, age, blood pressure (systolic and diastolic), number of prescribed drugs, associated other disease, side effect profile and table salt consumption considered. Conclusions: In this study we worked on various types of cardiovascular drugs and its effect on hypertension. From the study we saw that the patients are given different types of drugs such as Beta blocker, Calcium channel blocker, Diuretics etc. for lowering hypertension. The ultimate goal of this study was to find out the current prescription pattern of physicians for the management of hypertension.