40 years (odds ratio(OR) = 8.88), menopause (OR = 5.83), BMI > 40 kg/m2 (OR = 4.30), absence of regular moderate physical activity (OR = 5.44), absence of OCP usage (OR = 9.48), high carbohydrate intake (OR =2.01), and intake of high saturated fat (OR = 2.41) were the important lifestyle risk factorsassociated with the development of the gynecological malignancies. Majority (77.78%) of patients with ovarian carcinoma and all (100%) patients of carcinoma cervix belonged to the"low risk" groups, while majority (85%) of the patients of carcinoma endometrium belongedto the "high risk" group. Majority (96.55%) of the control subjects belonged to the "low risk" group. The difference of the risk categorization between the two groups was significant forpatients with ovarian carcinoma (P < 0.01) and endometrial carcinoma (P < 0.001), but not forpatients with carcinoma cervix (P = 0.56). Conclusions: Significant differences between thecases and the controls exist in terms of seven lifestyle risk factors out of the eleven consideredin our study. Majority of the patients of endometrial carcinoma belongs to "high risk" group, while majority of the patients of ovarian and cervical carcinoma belongs to "low risk" group" /> 40 years (odds ratio(OR) = 8.88), menopause (OR = 5.83), BMI > 40 kg/m2 (OR = 4.30), absence of regular moderate physical activity (OR = 5.44), absence of OCP usage (OR = 9.48), high carbohydrate intake (OR =2.01), and intake of high saturated fat (OR = 2.41) were the important lifestyle risk factorsassociated with the development of the gynecological malignancies. Majority (77.78%) of patients with ovarian carcinoma and all (100%) patients of carcinoma cervix belonged to the"low risk" groups, while majority (85%) of the patients of carcinoma endometrium belongedto the "high risk" group. Majority (96.55%) of the control subjects belonged to the "low risk" group. The difference of the risk categorization between the two groups was significant forpatients with ovarian carcinoma (P < 0.01) and endometrial carcinoma (P < 0.001), but not forpatients with carcinoma cervix (P = 0.56). Conclusions: Significant differences between thecases and the controls exist in terms of seven lifestyle risk factors out of the eleven consideredin our study. Majority of the patients of endometrial carcinoma belongs to "high risk" group, while majority of the patients of ovarian and cervical carcinoma belongs to "low risk" group" />

Association of lifestyle risk factors in common gynecological malignancies

Authors:Aditi Kishore Shinde, Soumyabrata Munshi, Subhash Chandra Biswas, Avijit Hazra, , Sasanka Chakrabarti,
Int J Biol Med Res. 2014; 5(3): 4293-4299  |  PDF File

Abstract

Background: Although many lifestyle factors affect the risk of development of gynecologicalmalignancies in women, some are unanimously accepted as important factors while others are not. Aims: The aim of the study was to determine the association of certain important lifestylefactors and development of gynecological carcinomas in patients attending a tertiary carehospital in eastern India. Materials & Methods: Administering an "11- point" lifestyle riskfactor questionnaire individually to 87 cases of gynecological malignancies and 87 controlsubjects, the study population was classified as "high risk" and "low risk". Association between the risk factors and the malignancies has been calculated. Results: Age > 40 years (odds ratio(OR) = 8.88), menopause (OR = 5.83), BMI > 40 kg/m2 (OR = 4.30), absence of regular moderate physical activity (OR = 5.44), absence of OCP usage (OR = 9.48), high carbohydrate intake (OR =2.01), and intake of high saturated fat (OR = 2.41) were the important lifestyle risk factorsassociated with the development of the gynecological malignancies. Majority (77.78%) of patients with ovarian carcinoma and all (100%) patients of carcinoma cervix belonged to the"low risk" groups, while majority (85%) of the patients of carcinoma endometrium belongedto the "high risk" group. Majority (96.55%) of the control subjects belonged to the "low risk" group. The difference of the risk categorization between the two groups was significant forpatients with ovarian carcinoma (P < 0.01) and endometrial carcinoma (P < 0.001), but not forpatients with carcinoma cervix (P = 0.56). Conclusions: Significant differences between thecases and the controls exist in terms of seven lifestyle risk factors out of the eleven consideredin our study. Majority of the patients of endometrial carcinoma belongs to "high risk" group, while majority of the patients of ovarian and cervical carcinoma belongs to "low risk" group