Histopathological spectrum of primary extranodal non hodgkin’s lymphomas in kashmir valley ; a 5 years study

Authors:Summyia farooq , Prof ruby reshi , Zhahid hassan , Naila nazir , Ambreen beigh , Farhat abass
Int J Biol Med Res. 2014; 5(4): 4654-4659  |  PDF File

Abstract

Background and Aim: The incidence of extra nodal non Hodgkin lymphoma (ENL) is rising throughout the world. However, data regarding ENL as a group is limited. The aim was to study the epidemiological and histomorphological trends of primary ENL (pENL) in Kashmir valley . Material and Methods: The biopsy materials from ninty six patients with pENL (64 male, 32 female, M:F= 2:1), diagnosed over a five year period (2008-2013), were analysed and pathologically reclassified according to the World Health Organization (WHO) classification, 2008 criteria. Results: Primary extra nodal non Hodgkin lymphomas constituted 24.0% (96/400) of all non Hodgkin lymphomas (NHL). The mean age at presentation for pENL and primary nodal NHL was 44.5 years and 58 years, respectively with a male predilection (M: F=2:1). Gastrointestinal tract (GIT) constituted the most common extranodal site (60/96, 62.5%) followed by Waldayer’s ring(28/96, 29.16%). Diffuse large B-cell lymphoma (DLBCL, not otherwise specified), extranodal marginal lymphoma of mucosa associated lymphoid tissue (MALT) type, and B cell NHL unclassified (U) were the three most common histological types observed. T-cell phenotype was rarely noted (4%). Follicular lymphomas and anaplastic large cell lymphoma, seen among nodal NHL, were absent at extra nodal sites. Majority (60/96, 64%) of the patients with pENL were immunocompetent and 55% were in stage I-II with favorable prognosis. Conclusion: Gastrointestinal tract was the most common site of ENL, followed by waldayer’s ring. Majority of pENL occurred in immunocompetent hosts with a favorable prognosis.