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Alteration in levels of serum calcium, phosphorous and magnesium in patients of hypothyroidism

Authors:Kavitha MM, Chandrashekharyya SH, SV Kashinakunti, Sunitha H, Neela BM, Sanjeev Ratna
Int J Biol Med Res. 2014; 5(4): 4594-4596  |  PDF File


Thyroid dysfunction constitutes the most common endocrine abnormality in the world second only to diabetes mellitus. Thyroid hormones play a central role in homeostasis of calcium and phosphorous levels in the body. Only few studies have been to find alterations of serum calcium, phosphorous and magnesium levels in subclinical hypothyroidism (SCH) and overt hypothyroidism (OH). Hence present study was aimed to find the changes in serum calcium, phosphorous and magnesium levels in SCH and OH and also correlate these parameters with serum TSH. Methodology: The study participants were selected from patients who have undergone thyroid profile evaluation. 50 subclinical hypothyroid patients, 50 overt hypothyroidism patients and 50 euthyroid patients were taken as control. Blood sample was collected from all these subjects and estimation of serum TSH, FT3, FT4, calcium, phosphorous and magnesium was done. Results: Our study shows the mean serum calcium levels were significantly (p<0.001) lower serum phosphorous and magnesium levels were significantly increased (p<0.01) in SCH and OH when compared to euthyroid. We also found there was statistically significant negative correlation between TSH and serum calcium positive correlation between TSH and serum phosphorous levels among both SCH and OH.