Assessment and comparison of electrophysiological findings in thyroid dysfunction patients of kanchipuram district.

Authors:Suchitra .B. Parkhad, *Sachin B Palve, Chandrashekhar M.C, Shankari P.
Int J Biol Med Res. 2015; 6(3): 5068-5071  |  PDF File


Background Thyroid dysfunction is a clinical condition associated with low levels of thyroid hormone (hypothyroidism) which produces variety of manifestations affecting peripheral nervous system. Objectives: To evaluate and compare the peripheral changes (neuromuscular dysfunction) by using electrophysiological tests in hypo thyroid patients and to compare the pattern of neuromuscular involvement between hypothyroidism and control group. Materials and methods: Prospective study was conducted in patients of kanchipuram district with diagnosed thyroid dysfunction 40 hypothyroid patients, and 40 controlled subjects. All participants were subjected to electro diagnostic evaluation. Results: There was significant polyneuropathy in hypothyroid patients but none was found in control group. There was significant polyneuropathy mainly axonal in hypothyroid groups but none in the control group. In upper limb 85% had sensory neuropathy and 20% have motor neuropathy among hypothyroid group. As for the lower limbs, 70% sensory neuropathy and 60% motor neuropathy among hypothyroid group. Entrapment neuropathy in the form of carpal tunnel syndrome was found in 30 %, 20% of the hypothyroid, and control group respectively. Conclusion: Thyroid dysfunction affects both central and peripheral nervous system, There is definite subclinical sensori -neurological involvement in early stages which can be assessed by nerve conduction studies and need to be intervened as early as and can be reversed by treatment.