Role of adipokines in periodontal disease with diabetes mellitus and without diabetes mellitus

Authors:Shiv Narayan Lahariya , Purnima Dey Sarkar ,Sunil Dwivedi
Int J Biol Med Res. 2015; 6(3): 5078-5081  |  PDF File


Abstract: Background: There is general agreement that there is a significant relationship between diabetes and periodontitis. Many studies have shown a high prevalence of periodontitis in diabetic patients. In addition a higher prevalence and more aggressive periodontitis are found in patients with poorly controlled diabetes. The duration of having diabetes is an important factor that affects the progression and severity of periodontitis. In this the adipokines play a significant role in diabetes mellitus type -2 and periodontal disease. Materials and Methods: A total of 150 periodontitis patients with diabetes mellitus and 150 periodontitis patients without diabetes mellitus have selected for the study. Fasting blood sugar and HbA1c, Resistin and Adiponectin levels have compared with 100 healthy non-diabetics, non -periodontitis subjects. Fasting blood sugar, HbA1c have done by semi auto-analyzer diagnostic kit and Resistin, Adiponectin by ELISA Method (Kit Method). Results: Analysis of resistin has showed a significant relationship between periodontal disease and in both diabetics and non-diabetics. Serum resistin levels in diabetics with periodontitis is 3.71 1.42 ng/ml, (p<0.0001), While in non-diabetics with periodontitis is 4.59 1.04 ng/ml, (p<0.0001) when compared to control groups (non-periodontitis and non- diabetics) 1.54 0.51 ng/ml. We confirm that resistin levels with T2DM are significantly higher than those of healthy subjects. Serum resistin also showed a significant (p<0.0001) positive correlation with HbA1c. Serum levels of adiponectin in the diabetics with periodontitis are slightly lower 4.48 0.96 (g/ml) than in non diabetics with periodontitis is 4.83 1.10 (g/ml) when compared to healthy subjects 6.951.21 (g/ml).This relationship showed a significant correlation with diabetes and periodontitis. BMI is significantly higher in the diabetics with periodontitis (p<0.0001). Age is not significant with the diabetics with periodontitis 43.33 10.08 and non-diabetics with periodontitis 43.877.30 when compared to healthy controls groups 41.53 6.37 and p<0.155. Periodontal parameters such as probing depth, attachment loss, bleeding index also have significant relationship with diabetics with periodontitis and non diabetics with periodontitis when compared to healthy control groups and p <0.0001. Conclusion: Periodontal disease and diabetes mellitus are closely associated and are highly prevalent chronic disease with many similarities in pathobiology. Diabetes can lead to several health complications, including periodontal disease. Periodontal disease or gum disease is one of the most common causes of teeth loss among diabetic patients.