Antidiabetic and hypolipidaemic effects of citrus aurantifolin leaves on diabetic and hyperglycaemic rats

Authors:HoweidaA. Mustafa , Eltaye B. Idris b, Ali M. Almahdi , Shaddad A. Sania , Mohammad H. Abdelwahhab
Int J Biol Med Res. 2015; 6(3): 5095-5099  |  PDF File

Abstract

Objective:This study aimed to investigate the hypoglycaemic and hypolipidaemic effects of Aqueous and methanol extracts of the leaves of C.aurantifolin inhyperglycaemic (type II) and in Streptozotocin diabetic rats (type I). Method: Type I was induced using Streptozotocin and type II, using a glucose loadingdose. Glucose tolerance test (GTT) was adopted.Result: Both doses of aqueous extract and dose 400 mg ∕ kg of the methanol extract,revealed a significant (P<0.001) persistent hypoglycaemic effect, in type II. Regarding blood cholesterol, aqueous extract showed an early, less persistent significant (P<0.001) hypocholesterolaemic effect in type II. Dose 400 mg/kg of the methanol extract, reduced cholesterol level significantly (P<0.05), at the 2nd and 4th hours, dose 200 mg/kg at the 1st and 2nd hours. In type I, dose 400 mg/kg and Insulin, showed a significant (P <0.05) hypocholesterolemic effect at the 4th hour and 8th hours. Dose 200mg/kg of the methanol extract revealed a significant (P <0.001) reduction at the 4th hour. Concerning blood triglycerides, both extracts, reduced blood triglycerides significantly (P <0.001) and (P<0.05), at the 2nd and 4th hours, respectively. In Type I, the effect of the aqueous extract was highly significant (P <0.001) and persistent. The methanol extract, reduced blood triglycerides significantly (P<0.05) 8 and 12 hours, while the effect of Insulin was significant (P<0.05) and persistent. Conclusion: Based on the findings of this study, it can be concluded that the leaves of C.aurantifolin, proved to be potent hypoglycaemic and hypolipidaemic medicinal plants. This confirms its traditional use