Blood group antigens and secretor phenotypes among voluntary blood donors and female sex workers in nairobi, kenya

Authors:NM Chanzu, W Mwanda, J Oyugi , O Anzala
Int J Biol Med Res. 2015; 6(4): 5325-5331  |  PDF File

Abstract

Background: Blood group antigens are collectively classified into major and minor blood group systems based on their serological characteristics. These antigens may also be found in mucosal secretions resulting in secretor or non-secretor phenotypes. In this regard, assessing blood group antigen frequency distribution is multipurpose, as besides their importance in blood transfusion, the correlation of these antigens is increasingly being sought in relation to disease. Aim: To determine ABO, Duffy and Rhesus (D) blood group antigen frequencies and secretor and non-secretor status among blood donors and female sex workers in Nairobi, Kenya. Methodology: Blood and saliva samples were obtained from 142 blood donors and 280 female sex workers. ABO, Rhesus (D), and Duffy blood grouping were done by standard haemagglutination techniques. Secretor and non-secretor phenotypes were determined by the agglutination inhibition method using anti-H lectins specific to salivary H antigen. Results: ABO frequency distribution was O>A>B>AB comprising 47.2%, 28.4%, 19.9% and 4.5% respectively with 96.7% Rhesus positive cases. Two (0.47%) of the study participants were Duffy positive and 78.9% were secretors and 21.1% non-secretors. Conclusion: This is the first report to document secretor and non-secretor phenotype frequencies in Kenya. The phenotype profiles are similar to previous reports on African populations