Histopathological patterns of endometrial lesions in patients with abnormal uterine bleeding- study of 500 cases

Authors:Hetal Rajendra Patel
Int J Biol Med Res. 2017; 8(2): 5995-6002  |  PDF File

Abstract

Abstract BACKGROUND: Abnormal Uterine Bleeding (AUB) is one of the most common and significant gynecological complaints and is seen in about 10-15% of women attending a gynecological clinic. It includes both organic and non organic causes of uterine bleeding. Histopathological study of endometrium plays an important role in its treatment. This study was done to understand the endometrial lesions and to determine the specific pathology in different age groups. AIM: Objectives of this study are to study the histopathological features, incidence and distribution of endometrial lesions and their relation to age, parity, BMI ( Body Mass Index). MATERIAL AND METHOD: This is a study of 500 endometrial lesions at our hospital over a period of 2 years from September 2013 to September 2015. All the clinical data of patients analyzed from hospital record files. RESULTS: Most of patients were in the age group 31-40 years and most of patients were with low parity and of normal weight. The main presenting complaint among patients was menorrhagia. Dysfunctional causes account for majority of the cases, in which proliferative endometrium was the commonest finding. The commonest histopathological finding amomg organic lesions was endometrial hyperplasia. Age specific comparative analysis of organic causes of abnormal uterine bleeding revealed that endometrial hyperplasia was commonest in perimenopausal women, while all the cases with endometrial carcinoma was found in postmenopausal women. CONCLUSION: The Histopathological examination of endometrial biopsy is a major diagnostic tool in evaluation of AUB and a specific diagnosis could help the gynecologist to plan therapy for successful management of AUB.This study was done to understand the endometrial lesions and to determine the specific pathology in different age groups.