Changes in metabolism of zinc andcarbohydrate and testis oxidative stress of diabetic rats fed zinc-over dose diet.

Authors:Samir Derouiche*, Abbas Kawther, Djermoune Manel
Int J Biol Med Res. 2017; 8(3): 6041-6045  |  PDF File

Abstract

The present study was designed to evaluate the effect ofdietary zinc on blood biochemical parameters, zinc levels and testis antioxidant status in Alloxan-induced in diabetic rats. The diabetic rats were divided into four groups (10 rates in each groups);the first group normal rats fed adequate diet (control group), the second group normal rats fed adequate diet supplemented with zinc (231 mg ZnCO4 7H2O /kg diet) (normal +Zn group), the third group diabetic rats fedadequate diet (diabetic group) and the fourth group diabetic rats fed adequate diet supplemented with zinc (231 mg ZnCO4 7H2O /kg diet) (diabetic +Zn group). Diabetes was induced by Alloxan (150 mg/kg) and zinc was added to the diet of the animals for 21 days. Results chewed that Diabetes caused a significant decrease in body weight gain, serum and testis zinc, serum amylase, alkaline phosphatase, aldolase and LDH activities, testis GSH, GPx and GST activities .In contrast, it led to an augmentation in blood glucose, triglycerides, cholesterol and testis MDA in rats. Zinc treatment in the diet for diabetic rats ensured a partial correction of the previous parameters. In conclusion, this study indicated that zinc act as powerful protective and antioxidants which may exercise adverse effect against metabolic disorder and testis complication of diabetes.