Spectrum of in vitro drug sensitivity of salmonella bacilli and clinical profile of typhoid patients presenting at a hospital in srinagar, india

Authors:Syed Arshad, Hussain, Parvaiz Ahmad Koul, Shamila Hamid , Imran Khan, Ab Wahid*, Javid iqbal wani
Int J Biol Med Res. 2017; 8(4): 6125-6127  |  PDF File

Abstract

Background: Enteric fever (typhoid) is the commonest ailment for which the medical treatment is sought in developing countries including India. The emergence of drug resistance to multiple drugs along with the varied clinical profile is a matter of high concern. Objective: The objective of this study was to assess the pattern of in vitro drug sensitivity of Salmonella typhi as also to assess clinical profile in enteric same patients. Design: It was an observational study carried over a period of 3 years in a tertiary hospital in culture positive salmonella typhi patients who were admitted in hospital for diagnosis and treatment. Material and methods: A total of 52 culture positive patients were recruited in first phase of study to assess the drug sensitivity pattern but in second phase clinical profile of only 36 patients out of 52 were studied. Sixteen were excluded in this phase as they were having additional medical problems like CRF, Liver diseases, malabsorption states leading to mix up of clinical features. Results: All the patients were found to be resistant to chloramphenicol and cloxacillin and sensitive to ceftriaxone, ciprofloxacin and nitrofurantoin. Pyrexia was the most common presentation in all the 36 patients (100%), Splenomegaly in 30 patients (80%). Least common symptom were headache and abdominal pain (5.5%).Conclusion: The occurrence of multidrug resistant enteric fever is very common now .There is drug resistance to those drugs which were previously called “Gold standard” .Ceftriaxone/nitrofurantoin /ciprofloxacin have taken the first place in management. The clinical features were almost similar but bleeding tendencies with variable gut signs and symptoms was noteworthy in some patients.