Cytogenetic study in lung carcinoma of north coastal andhra pradesh, india

Authors:Vasanthi Annapu , Pavani Sanapala , Srinivasa Rao Kodelli , Sudhakar Godi
Int J Biol Med Res. 2018; 9(1): 6183-6186  |  PDF File

Abstract

Tobacco smoking is the principal risk factor for the cause of lung cancer in South Asian countries. In India, males are more prone to risk than the females. Besides smoking, occupational exposure to industrialization and second-hand smoking are of minor causes. The change in cell metabolism and its function due to exposure of carcinogens that lead to structural abnormalities which are known as chromosomal aberrations. The present study is focused on the cytotoxicity and genotoxicity of the cells in lung cancer patients. Micronucleus assay (MN) was performed to assess the genotoxicity and cytotoxicity of the cells damaged in lung cancer cases and compared it with the control group. A sample size of 20 cases and 20 controls were taken. Males showed statistically high risk towards DNA damage than females. The mean age in the study is 50.5▒13.642. The frequency of chromosomal aberrations showed significant in cases than the control groups.