Correlation of serum and salivary glucose levels in diabetes mellitus patients

Authors:Sravya Kodati, Sumit Majumdar, Divya Uppala, Mitranki Rathi, Santhi Adigopula, Neeharika Mortha, Hyandavi Balla
Int J Biol Med Res. 2018; 9(2): 6321-6324  |  PDF File

Abstract

Introduction: Diabetes Mellitus (DM) is a metabolic disorder; it requires constant monitoring of glucose levels. Currently the diagnosis of diabetes is achieved only by analysing blood glucose levels, which is an invasive method and is physically and psychologically traumatic to the patient. This study is done to ascertain whether glucose present in saliva can be used to monitor the diabetes patients. Aim: This study is done to estimate and correlate the glucose levels in blood and saliva of diabetic patients, to assess if salivary glucose can be used as an alternative non-invasive tool for diagnosing and monitoring diabetes. Materials & methods: 200 diabetic patients were chosen for the study (100 controlled & 100 uncontrolled). 50 control subjects were age and gender matched. Quantitative estimation of glucose in the blood and saliva was performed by Hexokinase method. Glycosylated haemoglobin (Hba1c) levels were also estimated to confirm the diabetic status of the patient. Tabulation and Statistical analysis of the data was done. Results & Conclusion: Positive significant correlation between plasma and salivary glucose levels (<0.01). Salivary glucose was significantly higher in diabetics (<0.01). Significant positive correlation between glycosylated haemoglobin and salivary glucose levels (<0.01). The results showed that salivary glucose concentration can be used as a non-invasive tool for diagnosing and monitoring diabetic patients.