Correlation of serum & salivary ferritin levels in iron defeciency anemia patients

Authors:Sravya Kodati
Int J Biol Med Res. 2018; 9(2): 6317-6320  |  PDF File


Background: According to the World Health Organization (WHO), there exists two billion people in the world with anemia and half of them are due to iron deficiency. Iron deficiency anemia is one of the most important nutritional deficiencies in India. Its prevalence is higher in children of age group between 5–14 years, which is 48%. The assessment of serum ferritin has been the gold standard methods in the detection this disease. But, this involves the drawing of venous blood, which is invasive and is sometimes physically and psychologically traumatic to the child patients. This study is done to estimate and correlate the iron and ferritin levels in blood and saliva of children with iron deficiency anemia. Thus, assessing the effectiveness of saliva as an alternative non-invasive diagnostic tool. Aim: This study is done to estimate, compare and correlate the Ferritin, Iron, Total Iron Binding Capacity (TIBC) levels in serum & saliva of iron deficiency anemia patients, to determine whether saliva can be used as a predictive marker to monitor the iron levels in iron deficiency anemia. Materials & methods: 50 subjects were chosen for the study. Quantitative estimation of ferritin was performed by direct chemiluminiscence method. Total iron binding capacity was estimated by spectrophotometry. Percentage of saturation of iron is calculated, haemoglobin levels were also estimated to confirm the anemic status of the patient. Results & Conclusion: Decreased levels of iron and ferritin in serum and saliva of iron deficiency anemia patients compared to normal controls. Increased TIBC in serum and saliva of iron deficiency anemia patients. As the iron and ferritin levels decreases, TIBC increases. Saliva can be used as an alternative diagnostic tool to monitor the iron levels in anemia patients especially in children upto 12 years of age, when the iron deficiency is at its peak, thus it will aid to improve the quality of life of iron deficient individuals.