Synthesis, spectral and evaluation of biological activity of ni(ii) mixed ligand complex containing 2-aminothiazole and triphenylphosphine

Authors:Satish naik. Parameswaranaik P, Sunil kumar N. Krishnamurthy G, jithendra kumara K.S , Madhusudana somegowda
Int J Biol Med Res. 2018; 9(3): 6393-6399  |  PDF File

Abstract

A mixed ligand Ni(II) complex has been synthesized using 2-aminothiazole and triphenylphosphine in good yield. The structure was characterized by physico-chemical. The antimicrobial activity of the synthesized compound was evaluated against six bacterias (Staphylococcus aureus, Staphylococcus epidemidis , Bacillus cereus, P.aeruginosa, Vibrio cholerae and E. coli) and two phytopathogens fungi (Aspergillus aureus and Aspergillus fumigates) using standard method at MIC level. Further the compounds are subject to insilco molecular docking studies on antibacterial receptor 1STE, the lowest docking results concludes that the compounds showing good intarctions with amino acids at active sits of the receptor this evidence that the compounds binds to active sits of the receptor and suggesting that it can be a good antimicrobial agent. The complex showed significant antioxidant activity.