Palonosetron – a better antiemetic for management of ponv

Authors:Swati Adivarekar, Sandhya Gujar, Gajanan More, Harshraj Bhendale
Int J Biol Med Res. 2018; 9(2): 6352-6356  |  PDF File


Introduction: Postoperative nausea and vomiting is defined as nausea and vomiting occurring within 24 hrs after surgery. PONV is the most important complaint patient has, being equal to the pain after surgery. It is leading cause of unanticipated hospital admission after day care surgery. Middle ear surgeries are associated with highest incidence of N/V up to 80% because of associated Pathophysiology. Prophylaxis is indicated only in moderate to high risk surgeries as antiemetic agent itself has severe side effect as well as they increase the cost of treatment tremendously. Method: Palonosetron 0.075 mg and Ondensetron 8 mg as single intravenous dose immediately before induction of anaesthesia was studied as prophylactic measure to prevent or to decrease the incidence of PONV in a group of 60 patients. Result: Although various studies have concluded that there is no difference in efficacy of different types of 5H3 antagonists, we found that there was complete response without a single incidence of PONV in 80% of patients out of the 30 patients receiving Palonosetron. Conclusion: Prevention PONV is easier than its treatment. As middle ear surgeries are associated with high risk of developing PONV, it is concluded that prophylactic treatment with a single intravenous dose of Palanosetron is effective in treating PONV.