Adam33: role and pathogenesis study in copd in delhi ncr population

Authors:Smriti Gupta , Ajit Kumar, Vishwajeet Rohil, Anuj K. Bhatnagar
Int J Biol Med Res. 2019; 10(1): 6623-6630  |  PDF File

Abstract

Chronic Obstructive pulmonary disease (COPD) is caused by various environmental influences and genetic determinants. ADAM33, (Disintegrin, Metalloproteinase 33) is identified as one of the candidate gene playing an important role in airway pulmonary disease. Various studies have been conducted to reveal the genetic polymorphism of ADAM33. Our objective was to identify the role of ADAM33 in the blood serum samples of patients and its correlation with the FEV/FVC. The serum levels of ADAM33 from the blood samples were studied to correlate with the severity of the disease. The ADAM33 Single Nucleotide polymorphism was also studied to evaluate their association with COPD in Population of Delhi-NCR. The study was conducted on 100 patients at Rajan Babu Institute for Pulmonary Medicine & Tuberculosis (RJPIMT) Hospital. Patient diagnosis of COPD was confirmed by Spirometric test. Our result reveals a strong negative correlation was seen between FVC/FEV and ADAM33 for smoker group whereas weak correlation was seen between FEV/FVC and ADAM33 in non-smoker group of COPD patients. It also showed S1AA, ST+5AA were significantly more frequent in cases than in controls (P < 0.001). However T1, V4, ST+5 genotypes were found to be expressed more in the controls.