“sympathetic overactivity estimated by heart rate and blood pressure variability in rectal cancer patients”.

Authors:Aneta L. Zygulska*, Agata Furgala , Krzysztof Krzemieniecki, ShafeenMajidKoul*, B.S Pathania
Int J Biol Med Res. 2019; 10(4): 6871-6876  |  PDF File

Abstract

AIMS: The relationship between heart rate variability (HRV) and blood pressure variability (BPV) with respect to cardiovascular parameters and baroreceptor sensitivity has not previously been analyzed in rectal cancer patients. Spectral domain analysis of heart rate and blood pressure variability appears to be an effective tool for assessing parameters of autonomic nervous system function. METHODS: Therefore, 30 rectal cancer patients and 30 healthy volunteers were enrolled in this study. Autonomic nervous system (ANS) activities were evaluated by HRV and BPV. Electrocardiograms and blood pressure were recorded with linear and nonlinear analysis of HRV and spectral domain analysis of BPV at rest. RESULTS: The low frequency (LF) and high frequency (HF) resting HRV parameters of cancer patients were lower than those of control patients (LF, 195.4 vs. 316.5, p=0.002; HF, 115.2 vs. 398.6, p=0.002, respectively). The time domain (pNN50) and nonlinear analysis of HRV parameters (Poicare plot – SD2, SampleEnthrophy, DFAα1, DFAα2) were significantly lower in cancer patients than in the healthy controls. These results correlated with sympathetic overactivity. CONCLUSION: rectal cancer affects the sympathetic-parasympathetic balance by mediating sympathetic overactivity. These ANS abnormalities could be responsible for poor prognosis in rectal cancer and may cause motility dysfunction in the gastrointestinal tract.