A controlled randomized comparative study of effect of two different doses of dexmedetomidine for attenuation of the hemodynamic response to laryngoscopy and endotracheal intubation.

Abstract

Aims and Objective: To compare the effectiveness of two doses of intravenous dexmedetomidine, 0.5 µg/kg and 1 µg/kg body weight in attenuating hemodynamic response to laryngoscopy and intubation, Materials and Methods: A comparative study of 90 patients posted for elective surgery under general anaesthesia were randomly divided into 3 groups, group I received inj. Dexmedetomidine 0.5 µg/kg, group II received 1 µg/kg, and group III received 10 ml of normal saline, as infusion over 10 minutes. At the end of the infusion, patients were administered anaesthesia, intubated and maintained by using Sevoflurane inhalation. Cardiovascular parameters were recorded before infusion, at 5 minutes and 1 min. after end of infusion, 1 min. after induction, 1 min., 3 min., 5 min. and 10 min. after laryngoscopy and intubation. Ramsay sedation score and adverse effects were recorded, Statistical Analysis: The groups were compared using ANOVA (Analysis of Variance) in the form of one-way ANOVA test, and repeated measures ANOVA for the parametric interval measures. Intra-group variables were compared using student t test (paired). Quantitative data was compared using Non-parametric Chi-square test. Results of Quantitative data was presented as mean ± 2 SD. Results: statistical evaluation between the groups showed a highly significant fall in HR in groups I and II (p=0.00001) compared to the control group III. There was no statistically significant difference in mean HR in group I and II (p>0.05). Systolic Blood Pressure, Diastolic Blood pressure and Mean Arterial Pressure statistically showed significant stability in group I ad group II compared to group III. But there is no significant difference in group I and II. There were no adverse effects. Conclusion: Inj. Dexmedetomidine attenuate the hemodynamic response to laryngoscopy and endotracheal intubation and 0.5 µg/kg body weight is safer and equally efficacious compared to 1 µg/kg body weight.