Elevated plasma leptin levels in autistic children of sultanate of oman

Authors:Essa MM , Braidy N , Al-Sharbati MM , Al-Farsi YM , Ali A , Waly MI , Al-Shaffae MA , Gilles GJ
Int J Biol Med Res. 2011; 2(3): 803-805  |  PDF File

Abstract

Autistic spectrum disorders (ASD) are mysterious, complex, childhood pervasive developmental disorders characterized by impairments in social interaction, deficits in verbal and non-verbal communication, and restricted repetitive and stereotyped patterns of behavior and interests. The etiology of this disorder is poorly understood and no biomarkers have yet been identified as characteristic of ASD. Leptin, a peptide hormone mainly secreted by adipose tissue, is involved in the regulation of body weight and energy expenditure. Leptin also play a role in regulation of neuroendocrine functions, immune system and inflammatory response and development. Recent evidences suggest that leptin might be implicated in the pathophysiology of autism. Availability of biochemical data related with leptin for Omani autistic children is scarce. So, the current study was aimed to compare the levels of leptin in the plasma of ASD children in Sultanate of Oman. Significant higher levels of leptin were found in Omani autistic children as compared with controls. Our results corroborate with the previous findings and also suggest that there might be some relationship between leptin and the pathophysiology of autism. The exact mechanism is still unknown and further extensive research needed.