Assessment of lipid profile in patient of depression-a case control study

Authors:Sheetal Tripathi, Priyanka Sharma , A Q Jilani,Nitin Sharma,Shantanu Bharti, Ruchita Sharma.
Int J Biol Med Res. 2020; 11(3): 7067-7070  |  PDF File

Abstract

Background: Major depressive disorder (MDD) has a prevalence of around 4.4 % worldwide and would be a leading cause of disability by 2020 but etiological causations relating to MDD remains unclear. Lipids have a role in neuronal functioning and may have potential to be used as biomarkers in depression. The role of lipids in MDD is controversial. Majority of the studies have shown consistent relationships and few have shown no relationship. The assessment of lipid profile in patients of depression could be delineated by the results of present study which may add to the existing evidence. Material and methods: A total of 60 cases of MDD diagnosed as per ICD-10 criteria and 60 age and sex matched control were taken up. In both the groups we have measured lipid profile which includes serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), and very low-density lipoprotein cholesterol (VLDL). Results: The MDD subjects have lower levels of TC and LDL-cholesterol compared with healthy controls. Conclusion: Depression is associated with low serum cholesterol levels