Role of different natural compounds for potential treatment for their ability to be used as potential adjuncts in treating prostrate cancer

Abstract

In developed countries, Prostate cancer (PCa) is a major cause of cancer mortality among humans mainly in men. Tumor cells adapt the capability to escape cell death and develop resistance to existing therapies. There are many new curative approaches for the management of prostate cancer which involves cell death induction, tumor growth suppression, & inhibition of metastasis and angiogenesis in which the natural products have been commonly used for their anti-prostate cancer activities. A number of studies have been shown that the phytochemicals can particularly target the androgen receptor (AR) signaling ,as well as the prostate cancer stem cells (PCSCs). A number of clinical trials have been done to test the efficiency of nutraceuticals in human subjects, and they have partially confirmed the promising results obtained in vitro and in preclinical models. This review discusses about the anti-cancer mechanisms and curative capabilities of many different natural compounds in the prevention and treatment of prostate cancer in humans.