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ASSESSMENT OF THYROID FUNCTION STATUS IN CHRONIC KIDNEY DISEASE

Authors:P.SANGEETHA, G. POONGODI
Int J Biol Med Res. 2022; 13(2): 7445-7449  |  PDF File

Abstract

Background : There is an increasing prevalence of Chronic Kidney Disease and their associated metabolic alterations, thyroid dysfunction being one among them.. This study was conducted to find whether thyroid hormone dysfunction differs significantly in CKD patients compared to patients with normal kidney function. Objective: To compare the thyroid hormone levels (Free T3, Free T4, TSH), urea, creatinine, total protein and albumin between CKD patients and healthy controls attending OPD of Nephrology Department in Government Mohan Kumaramangalam Medical College Hospital, Salem. Materials and methods: 50 healthy controls and 50 patients with Chronic Kidney Disease attending Nephrology OPD of Government Mohan Kumaramangalam Medical College Hospital,were selected. After obtaining their informed written consent, Fasting and random blood sample were analyzed for thyroid hormone levels and Serum urea, creatinine, total protein and albumin. Result : There was a significant reduction in free T3 levels in CKD patients when compared to the healthy individuals. The mean Free T3 levels were 51.68 ng/dl in the CKD patients and 67.84 ng/dl in healthy control. There was no significant correlation between Free T4 levels (1.07636ng/dl in the CKD patients,1.21492 ng/dl in healthy controls) and TSH levels (2.61096 µIU/ml in the CKD patients, 2.5076 µIU/ml in healthy controls) of CKD patients when compared to the healthy individuals. The mean serum concentrations of Total Protein and albumin was 5.992 gms% and 3.295 gms% in CKD Patients whereas the controls had higher serum concentration of both which were 7.188 mgs% and 4.5612 mgs% respectively. Conclusion: This study proves and provides evidence for the prevalence of hypothyroidism in patients with Chronic Kidney Disease, Making it important for clinicians to diagnose it and treat it early to avoid any complications due to thyroid dysfunction.