Tender coconut water maintains the level of electrolytes and renin in fructose-fed hypertensive rats

Authors:Devarajan Bhagya , Lalitha Prema, Thankappan Rajamohan
Int J Biol Med Res. 2010; 1(3): 44 - 48  |  PDF File

Abstract

Studies on fructose induced hypertension have suggested that imbalance in electrolytes and renin –angiotensin-aldosterone system play an important role in the etiology. The present study evaluated the effect of Tender coconut water infusion on serum electrolytes, plasma L-Arginine, plasma renin activity and aldosterone levels on fructose-fed hypertensive rats. Male albino Sprague –Dawley rats were fed with high fructose diet (71%) and TCW was administered by gastric intubation (4ml/100g of body weight). The results showed that serum concentration of sodium was significantly (p<0.05) higher and serum potassium, calcium and magnesium were significantly lower in fructose-fed hypertensive rats compared to control which was mitigated on treatment with Tender coconut water. Concentration of Plasma L-Arginine was lowered in fructose fed rats were increased by tender coconut water supplementation. Plasma renin activity and aldosterone which was also increased in fructose fed rats was also lowered by the administration of Tender coconut water. Histopathological analysis of the kindney showed that Tender coconut water supplementation reverted the congestion and hypercellularity of glomerular tuft induced by high fructose diet. The study revealed that Tender coconut water was found to exert beneficial effects on electrolyte imbalance and elevated plasma renin activity and aldosterone in fructose fed hypertensive rats.