Effect of pranayama practicing on lipid peroxidation and antioxidants in coronary artery disease

Authors:Shashikant V. Nikam, Padmaja S. Nikam, Adinath N. Suryakar, Zunjarrao G. Badade, Kiran Nikam.
Int J Biol Med Res. 2010; 1(4): 153 – 157  |  PDF File

Abstract

ABSTRACT Yoga is a greatest Indian concept annunciated to the world. Accumulating evidences indicates that incidence and progression of coronary artery disease (CAD) may be modified by yoga. Free radicals play an important role in pathogenesis of tissue damage in many clinical disorders. Oxidative stress was assessed by estimating lipid peroxidation [LPO]. Activity of enzymatic antioxidants superoxide dismutase [SOD], glutathione peroxidase [GPx], catalase. The levels of heart profile enzymes creatine kinase (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) were measured in 60 patients of CAD ranging in age 40-60 years. Levels of plasma LPO, CK-MB, LDH, and AST were Significantly raised but activity of SOD, GPx, catalase, were significantly lowered in CAD on comparing with control groups. The study strongly indicates that after practicing of group of five pranayam (Bhastrika Pranayam, Kapalbhati Pranayam, Bhya Pranayam, Anulom-vilom Pranayam, Brahmari Pranayam) there was significantly increased activity of SOD, GPx and catalase. The study suggests that practicing of these five pranayama with drug therapy increases the activity of antioxidant enzymes and reduces the lipid peroxidation and heart profile enzymes which prevents cellular damage due to free radicals in CAD.