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The role of intravenous hydration and amino infusion in intrauterine growth restriction and oligohydramnios

Authors:Shivkumar PV, Tayade SA, Pramodkumar , Tayade AT , Bagde ND , Bagde MN
Int J Biol Med Res. 2011; 2(4): 1078 – 1083  |  PDF File

Abstract

Background: - The study was carried out to evaluate the role of maternal intravenous infusions in increasing the fetal weight and liquor amount in patients of intrauterine growth restriction and Oligohydramnios. Methods: Women with sonographically confirmed IUGR and Oligohydramnios were divided into 4 groups of 100 each. Group I women were hospitalized but received no infusion and were kept on high protein diet with bed rest. Group II recieved IV infusions of normal saline, ringer lactate and 5% dextrose in ratio of 2:1:2 (5 pints ) given on alternate days for 3 days in a week. Group III received amino acid drip 100 ml twice daily on alternate days for 3 days in a week. Group IV received Amino acid drip 100 ml twice daily on alternate days for 3 days in a week along with IV infusions of normal saline, ringer lactate, 5% dextrose in ratio of 2:1:2 (5 pints ) given on alternate days for 3 days in a week. Clinical assessment for foetal weight was done by maintaining gravidogram and liquor was assessed clinically as well as sonographically. Ultrasonography was done after one week of therapy and was repeated after two weeks. Results: AFI increased significantly in the groups who were given intravenous fluids and aminoacids. In groups which received aminoacids weight gain of foetus was much more as compared to groups receiving no treatment or only intravenous fluids. Maximum foetal weight gain was in group 1V i.e. 40 % between 400 to 500 grams. Normal deliveries without complications were much more in group 111 and 1V which was statistically significant. Caesarean section rate was significantly reduced in group 11, 111 & 1V as compared to group 1. In group 111 & 1V foetal distress was significantly reduced, babies born had better weight & intrauterine deaths were significantly reduced. Conclusion: We conclude that IV infusion of aminoacids , 5 % dextrose and normal saline if given as a week regimen on alternate days increases short term AFI and also improves foetal weight and thus has a beneficial effect to both mother and foetus in Intrauterine Growth Restriction and Idiopathic oligohydramnios.