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Are genetic factors really predisposing for essential hypertension?

Authors:Ashwini Kamble, Kanchan Mohod, Satish Kumar
Int J Biol Med Res. 2011; 2(4): 1198 -1203  |  PDF File

Abstract

Hypertension is a major risk factor for cardiovascular disorders such as stroke, heart failure, vascular disease, and end-stage renal disease, and is one of the leading causes of morbidity and mortality worldwide. While genes causing certain monogenic forms of human hypertension have been found; the current challenge is to identify and understand the admixture of genes causing hypertension in a majority of humans that has a polygenic basis. The convergence of global screening of gene expression patterns with extensive structural genomic information may be necessary to identify the gene clusters in hypertension that contributes to. This article reviews the recent progress, integrative efforts in the field and their extent to which genetic factors play a role in sustaining or modulating hypertension