Hyper vitaminosis a is associated with increased risk of hepatotoxicity in swiss albino mice

Abstract

Background: Vitamin A has essential impacts on area of health include vision, cellular differentiation, growth, reproduction, organ development during embryonic and membrane structure and function. Objective: The present study was conducted to evaluate the Hypervitaminosis A is associated with Increased Risk for hepatotoxicity in Swiss albino mice. Methods: Forty Swiss albino mice were randomly divided into four Groups of 10 animals each Group and dosed as follows: Group I, which was a control and given only corn oil (2 ml/kg body weight); Group II, III and IV were administered vitamin A orally (retinyl palmitate) 4000 I U/kg body weight/day/mice for four, eight and Twelve weeks of experimental period. Fasting blood samples were collected at the end of 4, 8 weeks and finally at the end of the study i.e.12 weeks for estimation of liver biomarker in all 4 Groups. Results: In the present study, the effect of hypervitaminosis A showed a significantly decreases (P<0.05) total proteins in the Group IV, compared to I, II, &III Group and no significant change (P>0.05) in the Group II relative to both control and III group. The of aspartate transaminase (AST), alanine transaminase(ALT), alkaline phosphatase (ALP) activity, Blood Glucose, serum calcium in the Group IV were significantly Increase (P<0.05) when compared to Control, II, III Group and no significant change (P>0.05) in the Group II compared to Control and Group III. Conclusion: It is concluded that chronic toxicity of hypervitaminosis A is associated with increased risk for hepatotoxicity in Swiss albino mice then acute toxicity.