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A correlative study of spirometric parameters and ecg changes in patients with chronic obstructive pulmonary disease

Authors:Niranjan Mambally Rachaiah, Jayasheelan Mambally Rachaiah , Rashmi Bhadravathi Krishnaswamy
Int J Biol Med Res. 2012; 3(1): 1322-1326  |  PDF File

Abstract

Context: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death world over. COPD has been defined as a disease state characterized by airflow limitation. Spirometric tests like Forced Expiratory Volume in first second (FEV1 ) < 80% and FEV1/FVC (ratio of Forced Expiratory Volume in first second to the Fixed Vital Capacity) 0.7 is the diagnostic criteria for COPD. COPD influences the electrical events of the heart. Aims: The objective was to observe ECG (electrocardiogram) changes and severity pattern by spirometry and to correlate the spirometric parameters with ECG changes. Settings and Design: A prospective cross sectional case control study. Methods and Material: 50 cases were selected on the basis of simple random sampling method. The FEV1, FEV1/FVC ratio and ECG changes such as P wave axis, QRS axis, P wave height ³ 2.5 mm and etc. were studied and the group of 20 non smoker healthy subjects were selected as a control. Spirometric parameters were correlated with ECG changes. Statistical analysis: Correlation between two variables were performed by Pearson’s correlation co-efficient “r”. Results: Majority of the patients had moderate (50%) and severe (42%) airflow limitation. The most common ECG changes were P wave axis ³ +90° (66%), QRS axis > +90° (42%), P wave height ³ 2.5 mm in lead II (42%). ECG changes significantly correlated with low values of FEV1/FVC ratio. Conclusion: Not only FEV1 and FEV1/FVC ratio helps to assess the severity of the disease, but also ECG would reflect the severity of COPD.