Effect of oxidative stress in pre and post hemodialysis in chronic renal failure patients

Abstract

This study was undertaken to evaluate the effect of oxidative stress in chronic renal failure patients before and after hemodialysis. The study comprised of 30 hemodialysis patients compared with 30 healthy controls. Blood samples were obtained from the patients before starting dialysis and one month later samples were collected from the same patients. Malondialdehyde (MDA) showed significant increase (p<0.001) in post dialysis compared to pre dialysis patients. Antioxidant enzymes such as superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase were significantly reduced in post dialysis (p<0.001) compared to pre dialysis and control group. The result of our study have shown a decrease in antioxidant enzyme activity in pre & post hemodialysis patients which is thought to be related to the loss of antioxidant enzymes through the membrane leading to increased lipid peroxidation.