Study of lipid profile in hypothyroidism

Authors:V. Sunanda, S. Sangeeta, B. Prabhakar rao
Int J Biol Med Res. 2012; 3(1): 1373-1376  |  PDF File

Abstract

Objective : It is uncertain whether hypothyroidism is associated with alterations of lipid profile in some sample populations. The present study aimed to assess the association between hypothyroidism and lipid levels. Design : Serum lipid parameters of 75 patients with different levels of TSH (related to hypothyroidism) and 25 age and sex matched euthyroids as controls were evaluated in a cross – sectional study. Methods : 75 cases of hypothyroidism in the age group of 20-60 years with 25 cases of age and sex matched euthyroids as controls were studied for thyroid profile over a period of 1 year and grouped on the basis of TSH levels as follows : Group I : 25 cases of normal healthy euthyroids as controls; Group II : 25 cases of TSH levels between 6-20 µIU/ml; Group III : 25 cases of TSH levels between 21-40 µIU/ml; Group IV : 25 cases of TSH level <40 µIU/ml. serum lipid profile parameters were analyzed in all the cases. Data was subjected to ANOVA, through SPSS version 17. Results : Group I : Mean and SD of serum total cholesterol, triglycerides, HDL-C and LDL-C were 163.4 ± 9.4, 122.2 ± 11.9, 39.3 ± 3.1 and 99.3 ± 7.2 mg/dl respectively. Group II : Mean and SD of total cholesterol, triglycerides, HDL and LDL were 204.7 ± 7.5, 165.4 ± 9.1, 43.8 ± 3.5 and 127.8 ± 5.2 mg/dl respectively. Group III : Mean and SD of total cholesterol, triglycerides, HDL and LDL were 214.9 ± 7.3, 166.5 ± 8.1, 44.3 ± 2.3 and 136.7 ± 4.9 mg/dl respectively. Group IV : Mean and SD of total cholesterol, triglycerides, HDL and LDL were 295.8 ± 21.4, 242.8 ± 33.2, 46.7 ± 1.7 and 199.9 ± 16.9 mg/dl respectively. Conclusions : Our data statistically suggest that the effect of hypothyroidism on the serum concentrations of lipids is more marked in patients with higher serum TSH levels. Therefore the lipid abnormalities exhibited great individual variability, there might be a potential link between hypothyroidism and atherosclerosis.