A study on correlation of serum prealbumin with other biochemical parameters of malnutrition in hemodialysis patient

Authors:M. Sathishbabu , S .Suresh
Int J Biol Med Res. 2012; 3(1): 1410-1412  |  PDF File

Abstract

Background: Malnutrition is more common in patients with end stage renal disease undergoing hemodialysis. The aim of the study was to assess the relation between serum prealbumin with other biochemical markers of malnutrition in patients with end stage renal disease undergoing hemodialysis. Method: 50 controls and 47 patients with chronic kidney disease on hemodialysis were enrolled in the study. Prealbumin, albumin, urea, creatinine, total cholesterol, prothrombin time and hsCRP was estimated in serum samples. Result: The data in the present study showed significant decrease in albumin, prealbumin, and increase in urea, creatinine in chronic kidney disease on hemodialysis . Also, we found significant correlation of prealbumin level with other biochemical parameters used for assessment of malnutrition with (p value <0.05), ROC analysis showed at optimum cutoff level of 29.5 mg/dl can predict malnutrition in person subjected to hemodialysis of stage 5 chronic kidney diseases with 72 % sensitivity and 60% specificity. Conclusion: The present study concludes that Prealbumin can be used surrogate marker of malnutrition when compared to other biochemical parameters of malnutrition in CKD patient on hemodialysis.