Clopidogrel and proton pump interaction- confusion, clear or clear confusion

Authors:Praveen Raj
Int J Biol Med Res. 4(): 74 - 75  |  PDF File


FDA has recently announced a box warning on clopidogrel package insert, as concomitant administration of clopidogrel along with a proton pump inhibitor leads to decrease in the effective concentration of clopidogrel active metabolite. Clopidogrel is an antiplatelet drug prescribed for the ACS; most of the time aspirin is also a co prescribed drug along with it. As most of the patients are elderly age group and polly pill taking, PPI is given to prevent and treat gastric ulcer. A trial recently evaluated the clopidogrel drug interactions has shown a significant mortality with Clopidogrel and PPI combination arm than clopidogrel alone.