Gastrointestinal stromal tumor - a clinicopathological study and its theraputic outcome in a tertiary care hospital

Authors:Rajesh Kumar N
Int J Biol Med Res. 2012; 3(2): 1532-1535  |  PDF File

Abstract

Objectives: The aim of the study is to determine the clinico-pathological features of primary gastrointestinal stromal tumors [GIST] and its therapeutic outcome in a Tertiary care Hospital, Tamil Nadu, India. Materials and methods: 16 patients with primary Gastrointestinal lymphoma[PGIL] diagnosed over a 6 year period from 2003 to 2008 were retrospectively and prospectively studied clinically and histopathologically they were classified using the Fletcher classification and a follow-up was till 2010 made for minimum three years from the date of diagnosis. Result: 16 patients (1.63%) were GIST arising out of 980 primary gastrointestinal malignancies, with a female to male ratio of 1.5: 1. All the patient were non vegetarians and majority of males were alcoholics and smokers. The mean age of the male patients was 46 years with age varying from 34 – 60 years, while for females, the mean age was 48 years, ranging from 40-70 years. Abdomen pain was the most common presenting symptom (70%), and the most common primary site was stomach (72.2%), followed by small bowl (16%), 95% of cases were CD 117 Positive. Surgery was considered in 90% of patients, liver was the main site of metastasis and the 3 years and the 4 years survival rate was 91% and 78% the use of Imatinib improved the rate of survival and post operative recurrence and the metastasis was decreased. Conclusion: Primary gastrointestinal stromal tumors constitute about 1.63 % of all gastricintestinal malignancies Abdomen pain was the common presenting symptom and stomach being the commonly involved site with female predominance. 95% of cases were CD 117 Positive The majority of the cases treated by surgery and the use of adjuvant imatinib had good prognosis with a 3 year and 5 years 91% and 78 % respectively.