Estimation of plasma antioxidants beta carotene, vitamin c and vitamin e levels in patients with osmf and oral cancer - indian population

Authors:L. Aravindh, P. Jagathesh, S. Shanmugam, Sonali Sarkar, P. Mahesh Kumar, S. Ramasubramanian
Int J Biol Med Res. 2012; 3(2): 1655 – 1657  |  PDF File

Abstract

Oxidants and antioxidants may play a role in the later stages of cancer development. There is increased evidence that oxidative process contributes to the promotion stages of carcinogenesis, at this stage the level of antioxidants are very crucial in prevention and progression of carcinogenesis. The human body has several in built mechanisms for defence against free radicals and other reactive oxygen species called anti oxidant systems, they act by scavenging them, suppressing their formation or opposing their actions. Epidemiological studies have suggested that high endogenous levels of pro oxidants and deficiencies in antioxidants level are likely to be important risk in the progression of pre cancer to cancer. Free radicals and other reactive oxygen species are difficult to measure quantitatively. Antioxidant nutrients which play a crucial role against defence of pro oxidants can be measured. If they are reduced from the normal level they can be supplemented. This study aims to evaluate the levels of antioxidants β-carotene, Vitamin C, Vitamin E, the most important antioxidant nutrients in Oral sub mucous fibrosis and Oral cancer. This study resulted in significant decrease in the levels of plasma micronutrients, β-carotene, Vitamin C and Vitamin E were observed as the lesion progresses from normal to pre cancer and then to cancer which in turn reflects the significant increase of oxidative stress in the progression of Oral sub mucous fibrosis to Oral cancer.