Diallyl disulphide modulates the behavioral arousal, lipid profile imbalance and redox status in experimental chronic hyperammonaemic rats.

Abstract

Aim: To investigate the effect of on Diallyl disulphide (DADS) on the lipid profile and antioxidant status in ammonium chloride (AC) induced hyperammonaemic rats. Methods: Male albino Wistar rats weighing 180–200 g were used for the study. The hyperammonemia was induced by interaperitonial injection (i.p) of AC (100 mg/kg body weight). Rats were treated with DADS (60 mg/kg body weight) via oral administration. The levels of lipid profiles; phospholipid, cholesterol and the antioxidants; catalase, glutathione peroxidase (GPX), vitamin-C, vitamin-E were studied, open field behavioral test such as peripheral movement, central movement, rearing and grooming were also carried in control and experimental rats. Results: Administration of DADS in hyperammonaemic rats reduced the levels of lipid profiles and there by reversing the oxidant-antioxidant imbalance during AC-induced hyperammonemia, and offered protection against hyperammonemia. Behavioral activities were significantly decreased in DADS treated hyperammonaemic rats when compared with control rats. Conclusion: The study offers evidence for the antihyperammonaemic, hepatoprotective and antioxidant effects of DADS against oxidative stress induced by AC.