Serum ferritin, iron, tibc, hb in male patients with dysglycemia

Authors:Arul Senghor, N Bharathy, JS Kumar, Ebenezer William, Balasubramaniam
Int J Biol Med Res. 2012; 3(2): 1609 – 1611  |  PDF File

Abstract

Diabetes Mellitus type 2 is one of the most common endocrine disorders affecting more than 135 million people in the world. Iron is a transitional metal and a potential catalyst in cellular reaction that produces reactive oxygen species. Ferritin is an index of body iron stores and acts as an iron overload marker. The study was conducted in 120 male subjects grouped as 60 diabetics and 60 pre-diabetics that include Impaired fasting glycemia (IFG) and Impaired glucose tolerance (IGT) patients attending the diabetic outpatient clinic. Exclusion criteria included anemia, recent surgery or any other disease or drug that could affect ferritin levels. This study was carried out to assess the levels of fasting blood sugar, 2 hour post-glucose (75 g of glucose) blood sugar, ferritin, Hb, iron, TIBC (Total Iron Binding Capacity) and compared with the duration of diabetes. Results were analyzed and compared with student‘t’ test. There was no significant difference in Hb, iron, TIBC between the two groups. Mean serum ferritin levels (224 ± 60.9 µg/L) was significantly higher in diabetes with the increased duration as compared with the pre-diabetic group. Thus increased ferritin levels, a marker of iron overload do assess indirectly the insulin resistance and risk of vascular complications in type 2 Diabetes mellitus.